研究の紹介

Research

老年期精神疾患研究グループ(業績)

神経病理学的研究

2014年
Nagao S, Yokota O, Ikeda C, Takeda N, Ishizu H, Kuroda S, Sudo K, Terada S, Murayama S, Uchitomi Y. Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. Eur Arch Psychiatry Clin Neurosci. 264(4): 317-331, 2014. doi: 10.1007/s00406-013-0472-6.
Ikeda C, Yokota O, Nagao S, Ishizu H, Morisada Y, Terada S, Nakashima Y, Akiyama H, Uchitomi Y. Corticobasal degeneration initially developing motor versus non-motor symptoms: a comparative clinicopathological study. Psychogeriatrics 14(3): 152-164, 2014. doi: 10.1111/psyg.12054.

2013年
Nagao S, Yokota O, Ikeda C, Terada S, Ihara Y, Uchitomi Y. Progressive supranuclear palsy presenting as primary lateral sclerosis. J Neurol Sci. 329(1-2): 70-71, 2013. doi: 10.1016/j.jns.2013.03.016

2012年
Takeda N, Yokota O, Terada S, Haraguchi T, Nobukuni K, Mizuki R, Honda H, Yoshida H, Kishimoto Y, Oshima E, Ishizu H, Satoh K, Kitamoto T, Ihara Y, Uchitomi Y. Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses: a clinicopathological study. J Neurol Sci. 312(1-2): 108-116, 2012. doi: 10.1016/j.jns.2011.08.008
Nagao S, Yokota O, Nanba R, Takata H, Haraguchi T, Ishizu H, Ikeda C, Takeda N, Oshima E, Sakane K, Terada S, Ihara Y, Uchitomi Y. Progressive supranuclear palsy presenting as primary lateral sclerosis but lacking parkinsonism, gaze palsy, aphasia, or dementia. J Neurol Sci. 323(1-2): 147-153, 2012. doi: 10.1016/j.jns.2012.09.005.

2011年
Haraguchi T, Terada S, Ishizu H, Yokota O, Yoshida H, Takeda N, Kishimoto Y, Katayama N, Takata H, Akagi M, Kuroda S, Ihara Y, Uchitomi Y. Coexistence of TDP-43 and tau pathology in neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome). Neuropathology 31: 531-539, 2011.

2010年
Yoshida H, Terada S, Ishizu H, Ikeda K, Hayabara T, Ikeda K, Deguchi K, Touge T, Kitamoto T, Kuroda S. An autopsy case of Creutzfeldt-Jakob disease with a V180I mutation of the PrP gene and Alzheimer-type pathology. Neuropathology 30: 159-164, 2010.
Yokota O, Davidson Y, Bigio EH, Ishizu H, Terada S, Arai T, Hasegawa M, Akiyama H, Sikkink S, Pickering-Brown S, Mann DM. Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy. Acta Neuropathol. 120: 55-66, 2010.
Yokota O, Davidson Y, Arai T, Hasegawa M, Akiyama H, Ishizu H, Terada S, Sikkink S, Pickering-Brown S, Mann DM. Effect of topographical distribution of alpha-synuclein pathology on TDP-43 accumulation in Lewy body disease. Acta Neuropathol. 120: 789-801, 2010.

大学病院での臨床研究

2015年
Ikeda C, Terada S, Oshima E, Hayashi S, Okahisa Y, Takaki M, Inagaki M, Yokota O, Uchitomi Y. Difference in determinants of caregiver burden between amnestic mild cognitive impairment and mild Alzheimer's disease. Psychiatry Res. 226(1): 242-246, 2015. doi: 10.1016/j.psychres.2014.12.055.

2014年
Oshima E, Terada S, Sato S, Ikeda C, Oda K, Inoue S, Kawada K, Yokota O, Uchitomi Y. Left frontal lobe hypoperfusion and depressive symptoms in Alzheimer's disease patients taking cholinesterase inhibitors. Psychiatry Res. 224(3): 319-323, 2014. doi: 10.1016/j.pscychresns.2014.10.008.
Terada S, Oshima E, Sato S, Ikeda C, Nagao S, Hayashi S, Hayashibara C, Yokota O, Uchitomi Y. Depressive symptoms and regional cerebral blood flow in Alzheimer's disease. Psychiatry Res. 221(1): 86-91, 2014. doi: 10.1016/j.pscychresns.2013.11.002.
Honda H, Terada S, Sato S, Oshima E, Ikeda C, Nagao S, Yokota O, Uchitomi Y. Subjective depressive mood and regional cerebral blood flow in mild Alzheimer’s disease. Int Psychogeriatr. 26(5): 817-823, 2014. doi: 10.1017/S1041610213002573

2013年
Shindo A, Terada S, Sato S, Ikeda C, Nagao S, Oshima E, Yokota O, Uchitomi Y. Trail making test A and brain perfusion imaging in mild Alzheimer’s disease. Dement Geriatr Cogn Dis Extra. 3(1): 202-211, 2013. doi: 10.1159/000350806
Hayashi S, Terada S, Nagao S, Ikeda C, Shindo A, Oshima E, Yokota O, Uchitomi Y. Burden of caregivers for patients with mild cognitive impairment in Japan. Int Psychogeriatr. 25(8): 1357-1363, 2013. doi: 10.1017/S1041610213000537
Terada S, Sato S, Nagao S, Ikeda C, Shindo A, Hayashi S, Oshima E, Yokota O, Uchitomi Y. Trail making test B and brain perfusion imaging in mild cognitive impairment and mild Alzheimer’s disease. Psychiatry Res. 213(3): 249-255, 2013. doi: 10.1016/j.pscychresns.2013.03.006
Kishimoto Y, Terada S, Takeda N, Oshima E, Honda H, Yoshida H, Yokota O, Uchitomi Y. Abuse of people with cognitive impairment by family caregivers in Japan (a cross-sectional study). Psychiatry Res. 209(3): 699-704, 2013. doi: 10.1016/j.psychres.2013.01.025

2012年
Yoshida H, Terada S, Honda H, Kishimoto Y, Takeda N, Oshima E, Hirayama K, Yokota O, Uchitomi Y. Validation of the revised Addenbrooke's Cognitive Examination (ACE-R) for detecting mild cognitive impairment and dementia in a Japanese population. Int Psychogeriatr. 24(1): 28-37, 2012. doi: 10.1017/S1041610211001190
Oshima E, Terada S, Sato S, Ikeda C, Nagao S, Takeda N, Honda H, Yokota O, Uchitomi Y. Frontal assessment battery and brain perfusion imaging in Alzheimer's disease. Int Psychogeriatr. 24(6): 994-1001, 2012. doi: 10.1017/S1041610211002481

2011年
Yoshida H, Terada S, Honda H, Ata T, Takeda N, Kishimoto Y, Ohshima E, Ishihara T, Kuroda S. Validation of Addenbrooke’s cognitive examination for detecting early dementia in a Japanese population. Psychiatry Res. 185: 211-214, 2011.
Kishimoto Y, Terada S, Sato S, Takeda N, Honda H, Yokota O, Uchitomi Y. Kana Pick-out Test and brain perfusion imaging in Alzheimer's disease. Int Psychogeriatr. 23(4): 546-553, 2011. doi: 10.1017/S1041610210001961
Terada S, Sato S, Honda H, Kishimoto Y, Takeda N, Oshima E, Yokota O, Uchitomi Y. Perseverative errors on Wisconsin card sorting test and brain perfusion imaging in mild Alzheimer’s disease. Int. Psychogeriatr. 23: 1552-1559, 2011.

2010年
Takeda N, Terada S, Sato S, Honda H, Yoshida H, Kishimoto Y, Kamata G, Oshima E, Ishihara T, Kuroda S. Wisconsin Card Sorting Test and Brain Perfusion Imaging in Early Dementia. Dement. Geriatr. Cogn. Disord. 29: 21-27, 2010.
Kishimoto Y, Terada S, Sato S, Yoshida H, Honda H, Takeda N, Oshima E, Ishihara T, Kuroda S. Repetitive questioning behavior in Alzheimer’s disease: relationship to regional cerebral blood flow. Psychiatry Res. 184: 151-156, 2010.

関連病院との共同研究

2015年
Terada S, Oshima E, Ikeda C, Hayashi S, Yokota O, Uchitomi Y. Development and evaluation of a short version of the quality of life questionnaire for dementia. Int Psychogeriatr. 27(1): 103-110, 2015. doi: 10.1017/S1041610214001811.

2013年
Terada S, Oshima E, Yokota O, Ikeda C, Nagao S, Takeda N, Sasaki K, Uchitomi Y. Person-centered care and quality of life of patients with dementia in long-term care facilities. Psychiatry Res. 205(1-2): 103-108, 2013. doi: 10.1016/j.psychres.2012.08.028

2010年
Ata T, Terada S, Yokota O, Ishihara T, Fujisawa Y, Sasaki K, Kuroda S. Wandering and fecal smearing in people with dementia. Int. Psychogeriatr. 22: 493-500, 2010.

動物モデルを用いた研究

2014年
Oshima E, Ishihara T, Yokota O, Nakashima-Yasuda H, Nagao S, Ikeda C, Naohara J, Terada S, Uchitomi Y. Accelerated tau aggregation, apoptosis, and neurological dysfunction due to chronic oral administration of aluminum in a mouse model of tauopathies. Brain Pathol. 23(6): 633-644, 2013. doi: 10.1111/bpa.12059