老年期精神疾患研究グループ（業績）｜研究の紹介｜岡山大学大学院精神神経病態学教室

老年期精神疾患研究グループ（業績）

神経病理学的研究

2018年
Miki T, Yokota O, Takenoshita S, Mori Y, Yamazaki K, Ozaki Y, Ueno SI, Haraguchi T, Ishizu H, Kuroda S, Terada S, Yamada N. Frontotemporal lobar degeneration due to P301L tau mutation showing apathy and severe frontal atrophy but lacking other behavioral changes: A case report and literature review. Neuropathology. 2017 Nov 6. doi: 10.1111/neup.12441.
Yokota O, Miki T, Ikeda C, Nagao S, Takenoshita S, Ishizu H, Haraguchi T, Kuroda S, Terada S, Yamada N. Neuropathological comorbidity associated with argyrophilic grain disease. Neuropathology. 38(1): 82-97, 2018. doi: 10.1111/neup.12429.

2017年
Ikeda C, Yokota O, Miki T, Takenoshita S, Ishizu H, Mori Y, Yamazaki K, Ozaki Y, Ueno SI, Ishihara T, Hasegawa M, Terada S, Yamada N. Pick's disease with neuronal four-repeat tau accumulation in the basal ganglia, brain stem nuclei and cerebellum. Neuropathology. 37(6): 544-559, 2017. doi: 10.1111/neup.12394.
Oyanagi K, Kinoshita M, Suzuki-Kouyama E, Inoue T, Nakahara A, Tokiwai M, Arai N, Satoh JI, Aoki N, Jinnai K, Yazawa I, Arai K, Ishihara K, Kawamura M, Ishizawa K, Hasegawa K, Yagisita S, Amano N, Yoshida K, Terada S, Yoshida M, Akiyama H, Mitsuyama Y, Ikeda SI. Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and Nasu-Hakola disease: lesion staging and dynamic changes of axons and microglial subsets. Brain Pathol. 27(6): 748-769, 2017. doi: 10.1111/bpa.12443.

2016年
Miki T, Yokota O, Ishizu H, Kuroda S, Oshima E, Terada S, Yamada N. Behavioral variant of frontotemporal dementia: Fundamental clinical issues associated with prediction of pathological bases. Neuropathology. 36(4): 388-404, 2016. doi: 10.1111/neup.12290.
Ikeda C, Yokota O, Nagao S, Ishizu H, Oshima E, Hasegawa M, Okahisa Y, Terada S, Yamada N. The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease. Brain Pathol. 26(4): 488-505, 2016. doi: 10.1111/bpa.12319.
Watanabe Y, Beeldman E, Raaphorst J, Izumi Y, Yoshino H, Masuda M, Atsuta N, Ito S, Adachi T, Adachi Y, Yokota O, Oda M, Hanashima R, Ogino M, Ichikawa H, Hasegawa K, Kimura H, Shimizu T, Aiba I, Yabe H, Kanba M, Kusumi K, Aoki T, Hiroe Y, Watanabe H, Nishiyama K, Nomoto M, Sobue G, Nakashima K; ALS-FTD-Q-J Research Group. Japanese version of the ALS-FTD-Questionnaire (ALS-FTD-Q-J). J Neurol Sci. 367: 51-55, 2016. doi: 10.1016/j.jns.2016.05.036.
Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H. Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration. Acta Neuropathol Commun. 4: 36, 2016. doi: 10.1186/s40478-016-0304-9.

2014年
Oshima E, Ishihara T, Yokota O, Nakashima-Yasuda H, Nagao S, Ikeda C, Naohara J, Terada S, Uchitomi Y. Accelerated tau aggregation, apoptosis, and neurological dysfunction due to chronic oral administration of aluminum in a mouse model of tauopathies. Brain Pathol. 23(6): 633-644, 2013. doi: 10.1111/bpa.12059.
Nagao S, Yokota O, Ikeda C, Takeda N, Ishizu H, Kuroda S, Sudo K, Terada S, Murayama S, Uchitomi Y. Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. Eur Arch Psychiatry Clin Neurosci. 264(4): 317-331, 2014. doi: 10.1007/s00406-013-0472-6.
Ikeda C, Yokota O, Nagao S, Ishizu H, Morisada Y, Terada S, Nakashima Y, Akiyama H, Uchitomi Y. Corticobasal degeneration initially developing motor versus non-motor symptoms: a comparative clinicopathological study. Psychogeriatrics 14(3): 152-164, 2014. doi: 10.1111/psyg.12054.

2013年
Nagao S, Yokota O, Ikeda C, Terada S, Ihara Y, Uchitomi Y. Progressive supranuclear palsy presenting as primary lateral sclerosis. J Neurol Sci. 329(1-2): 70-71, 2013. doi: 10.1016/j.jns.2013.03.016
Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H. Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases. J Neurol Sci. 335(1-2): 89-95, 2013. doi: 10.1016/j.jns.2013.08.035.
Kobayashi Z, Arai T, Yokota O, Tsuchiya K, Hosokawa M, Oshima K, Niizato K, Akiyama H, Mizusawa H. Atypical FTLD-FUS associated with ALS-TDP: a case report. Neuropathology. 33(1): 83-86, 2013. doi: 10.1111/j.1440-1789.2012.01325.x.

2012年
Takeda N, Yokota O, Terada S, Haraguchi T, Nobukuni K, Mizuki R, Honda H, Yoshida H, Kishimoto Y, Oshima E, Ishizu H, Satoh K, Kitamoto T, Ihara Y, Uchitomi Y. Creutzfeldt-Jakob disease with the M232R mutation in the prion protein gene in two cases showing different disease courses: a clinicopathological study. J Neurol Sci. 312(1-2): 108-116, 2012. doi: 10.1016/j.jns.2011.08.008
Nagao S, Yokota O, Nanba R, Takata H, Haraguchi T, Ishizu H, Ikeda C, Takeda N, Oshima E, Sakane K, Terada S, Ihara Y, Uchitomi Y. Progressive supranuclear palsy presenting as primary lateral sclerosis but lacking parkinsonism, gaze palsy, aphasia, or dementia. J Neurol Sci. 323(1-2): 147-153, 2012. doi: 10.1016/j.jns.2012.09.005.
Neumann M, Valori CF, Ansorge O, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ishihara K, Ang LC, Bilbao JM, Mackenzie IR. Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations. Acta Neuropathol. 124(5): 705-716, 2012. doi: 10.1007/s00401-012-1020-6.

2011年
Haraguchi T, Terada S, Ishizu H, Yokota O, Yoshida H, Takeda N, Kishimoto Y, Katayama N, Takata H, Akagi M, Kuroda S, Ihara Y, Uchitomi Y. Coexistence of TDP-43 and tau pathology in neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome). Neuropathology 31(5): 531-539, 2011.
Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IR. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain. 134(Pt 9): 2595-2609, 2011. doi: 10.1093/brain/awr201.
Kobayashi Z, Tsuchiya K, Komachi H, Miki K, Yokota O, Arai T, Miake H, Ishizu H, Akiyama H, Mizusawa H. Fatal encephalitis in a case of hypereosinophilic syndrome: MRI and autopsy findings. Intern Med. 50(11): 1219-1225, 2011.
Dakson A, Yokota O, Esiri M, Bigio EH, Horan M, Pendleton N, Richardson A, Neary D, Snowden JS, Robinson A, Davidson YS, Mann DM. Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology. Acta Neuropathol. 121(5): 635-649, 2011. doi: 10.1007/s00401-011-0798-y.
Mackenzie IR, Munoz DG, Kusaka H, Yokota O, Ishihara K, Roeber S, Kretzschmar HA, Cairns NJ, Neumann M. Distinct pathological subtypes of FTLD-FUS. Acta Neuropathol. 121(2): 207-218, 2011. doi: 10.1007/s00401-010-0764-0.

2010年
Yoshida H, Terada S, Ishizu H, Ikeda K, Hayabara T, Ikeda K, Deguchi K, Touge T, Kitamoto T, Kuroda S. An autopsy case of Creutzfeldt-Jakob disease with a V180I mutation of the PrP gene and Alzheimer-type pathology. Neuropathology 30(2): 159-164, 2010.
Yokota O, Davidson Y, Bigio EH, Ishizu H, Terada S, Arai T, Hasegawa M, Akiyama H, Sikkink S, Pickering-Brown S, Mann DM. Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy. Acta Neuropathol. 120(1): 55-66, 2010.
Yokota O, Davidson Y, Arai T, Hasegawa M, Akiyama H, Ishizu H, Terada S, Sikkink S, Pickering-Brown S, Mann DM. Effect of topographical distribution of alpha-synuclein pathology on TDP-43 accumulation in Lewy body disease. Acta Neuropathol. 120(6): 789-801, 2010.
Kobayashi Z, Tsuchiya K, Arai T, Yokota O, Yoshida M, Shimomura Y, Kondo H, Haga C, Asaoka T, Onaya M, Ishizu H, Akiyama H, Mizusawa H. Clinicopathological characteristics of FTLD-TDP showing corticospinal tract degeneration but lacking lower motor neuron loss. J Neurol Sci. 298(1-2): 70-77, 2010. doi: 10.1016/j.jns.2010.08.013.
Kobayashi Z, Tsuchiya K, Arai T, Yokota O, Watabiki S, Ishizu H, Akiyama H, Mizusawa H. Pseudopolyneuritic form of ALS revisited: clinical and pathological heterogeneity. Neuropathology. 30(4): 372-380, 2010. doi: 10.1111/j.1440-1789.2009.01084.x.
Kobayashi Z, Tsuchiya K, Takahashi M, Yokota O, Taki K, Ishizu H, Arai T, Akiyama H, Mizusawa H. Morel's laminar sclerosis showing apraxia of speech: distribution of cortical lesions in an autopsy case. Neuropathology.30(1): 76-83, 2010. doi: 10.1111/j.1440-1789.2009.01039.x.

認知症の臨床研究

2018年
Takenoshita S, Terada S, Yokota O, Kutoku Y, Wakutani Y, Nakashima M, Maki Y, Hattori H, Yamada N. Sally-Anne Test in Patients with Alzheimer's Disease Dementia. J Alzheimers Dis. 61(3): 1029-1036, 2018. doi: 10.3233/JAD-170621.
Hayashi S, Terada S, Oshima E, Sato S, Kurisu K, Takenoshita S, Yokota O, Yamada N. Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease. Dement Geriatr Cogn Dis Extra. 8(1): 1-11, 2018. doi: 10.1159/000486093.
Fukuda K, Terada S, Hashimoto M, Ukai K, Kumagai R, Suzuki M, Nagaya M, Yoshida M, Hattori H, Murotani K, Toba K. Effectiveness of educational program using printed educational material on care burden distress among staff of residential aged care facilities without medical specialists and/or registered nurses: Cluster quasi-randomization study. Geriatr Gerontol Int. 18(3): 487-494, 2018. doi: 10.1111/ggi.13207.

2017年
Takenoshita S, Kondo K, Okazaki K, Hirao A, Takayama K, Hirayama K, Asaba H, Nakata K, Ishizu H, Takahashi H, Nakashima-Yasuda H, Sakurada Y, Fujikawa K, Yokota O, Yamada N, Terada S; Middle Western Japan-Dementia Study (mid-Dem study). Tube feeding decreases pneumonia rate in patients with severe dementia: comparison between pre- and post-intervention. BMC Geriatr. 17(1): 267, 2017. doi: 10.1186/s12877-017-0662-6.
Takayama K, Hirayama K, Hirao A, Kondo K, Hayashi H, Kadota K, Asaba H, Ishizu H, Nakata K, Kurisu K, Oshima E, Yokota O, Yamada N, Terada S. Survival times with and without tube feeding in patients with dementia or psychiatric diseases in Japan. Psychogeriatrics. 17(6): 453-459, 2017. doi: 10.1111/psyg.12274.

2016年
Hayashi S, Terada S, Sato S, Oshima E, Miki T, Yokota O, Ishihara T, Yamada N. Positive affect and regional cerebral blood flow in Alzheimer's disease. Psychiatry Res.256: 15-20, 2016. doi: 10.1016/j.pscychresns.2016.09.003.
Kurisu K, Terada S, Oshima E, Horiuchi M, Imai N, Yabe M, Yokota O, Ishihara T, Yamada N. Comparison of QOL between patients with different degenerative dementias, focusing especially on positive and negative affect. Int Psychogeriatr. 28(8): 1355-1361, 2016. doi: 10.1017/S1041610216000491.
Abe K, Yamashita R, Kondo K, Takayama K, Yokota O, Sato Y, Kawai M, Ishizu H, Nakashima T, Hayashi H, Nakata K, Asaba H, Kadota K, Tanaka K, Morisada Y, Oshima E, Terada S. Long-Term Survival of Patients Receiving Artificial Nutrition in Japanese Psychiatric Hospitals. Dement Geriatr Cogn Dis Extra.6(3): 477-485, 2016.
Hirao A, Abe K, Takayama K, Kondo K, Yokota O, Sato Y, Norikiyo T, Sato S, Nakashima T, Hayashi H, Nakata K, Asaba H, Tanaka K, Tanaka R, Morisada Y, Itakura H, Honda H, Okabe N, Oshima E, Terada S; Middle Western Japan-Dementia Study (mid-Dem study). Heterogeneity of patients receiving artificial nutrition in Japanese psychiatric hospitals: a cross-sectional study. Psychogeriatrics. 16(6): 341-348, 2016. doi: 10.1111/psyg.12173.

2015年
Ikeda C, Terada S, Oshima E, Hayashi S, Okahisa Y, Takaki M, Inagaki M, Yokota O, Uchitomi Y. Difference in determinants of caregiver burden between amnestic mild cognitive impairment and mild Alzheimer's disease. Psychiatry Res. 226(1): 242-246, 2015. doi: 10.1016/j.psychres.2014.12.055.
Terada S, Oshima E, Ikeda C, Hayashi S, Yokota O, Uchitomi Y. Development and evaluation of a short version of the quality of life questionnaire for dementia. Int Psychogeriatr. 27(1): 103-110, 2015. doi: 10.1017/S1041610214001811.

2014年
Oshima E, Terada S, Sato S, Ikeda C, Oda K, Inoue S, Kawada K, Yokota O, Uchitomi Y. Left frontal lobe hypoperfusion and depressive symptoms in Alzheimer's disease patients taking cholinesterase inhibitors. Psychiatry Res. 224(3): 319-323, 2014. doi: 10.1016/j.pscychresns.2014.10.008.
Terada S, Oshima E, Sato S, Ikeda C, Nagao S, Hayashi S, Hayashibara C, Yokota O, Uchitomi Y. Depressive symptoms and regional cerebral blood flow in Alzheimer's disease. Psychiatry Res. 221(1): 86-91, 2014. doi: 10.1016/j.pscychresns.2013.11.002.
Honda H, Terada S, Sato S, Oshima E, Ikeda C, Nagao S, Yokota O, Uchitomi Y. Subjective depressive mood and regional cerebral blood flow in mild Alzheimer’s disease. Int Psychogeriatr. 26(5): 817-823, 2014. doi: 10.1017/S1041610213002573

2013年
Shindo A, Terada S, Sato S, Ikeda C, Nagao S, Oshima E, Yokota O, Uchitomi Y. Trail making test A and brain perfusion imaging in mild Alzheimer’s disease. Dement Geriatr Cogn Dis Extra. 3(1): 202-211, 2013. doi: 10.1159/000350806
Hayashi S, Terada S, Nagao S, Ikeda C, Shindo A, Oshima E, Yokota O, Uchitomi Y. Burden of caregivers for patients with mild cognitive impairment in Japan. Int Psychogeriatr. 25(8): 1357-1363, 2013. doi: 10.1017/S1041610213000537
Terada S, Sato S, Nagao S, Ikeda C, Shindo A, Hayashi S, Oshima E, Yokota O, Uchitomi Y. Trail making test B and brain perfusion imaging in mild cognitive impairment and mild Alzheimer’s disease. Psychiatry Res. 213(3): 249-255, 2013. doi: 10.1016/j.pscychresns.2013.03.006
Kishimoto Y, Terada S, Takeda N, Oshima E, Honda H, Yoshida H, Yokota O, Uchitomi Y. Abuse of people with cognitive impairment by family caregivers in Japan (a cross-sectional study). Psychiatry Res. 209(3): 699-704, 2013. doi: 10.1016/j.psychres.2013.01.025
Terada S, Oshima E, Yokota O, Ikeda C, Nagao S, Takeda N, Sasaki K, Uchitomi Y. Person-centered care and quality of life of patients with dementia in long-term care facilities. Psychiatry Res. 205(1-2): 103-108, 2013. doi: 10.1016/j.psychres.2012.08.028

2012年
Yoshida H, Terada S, Honda H, Kishimoto Y, Takeda N, Oshima E, Hirayama K, Yokota O, Uchitomi Y. Validation of the revised Addenbrooke's Cognitive Examination (ACE-R) for detecting mild cognitive impairment and dementia in a Japanese population. Int Psychogeriatr. 24(1): 28-37, 2012. doi: 10.1017/S1041610211001190
Oshima E, Terada S, Sato S, Ikeda C, Nagao S, Takeda N, Honda H, Yokota O, Uchitomi Y. Frontal assessment battery and brain perfusion imaging in Alzheimer's disease. Int Psychogeriatr. 24(6): 994-1001, 2012. doi: 10.1017/S1041610211002481
Inoue S, Terada S, Matsumoto T, Ujike H, Uchitomi Y. A case of adult-onset adrenoleukodystrophy with frontal lobe dysfunction: a novel point mutation in the ABCD1 gene. Intern Med. 51(11): 1403-1406, 2012.

2011年
Yoshida H, Terada S, Honda H, Ata T, Takeda N, Kishimoto Y, Ohshima E, Ishihara T, Kuroda S. Validation of Addenbrooke’s cognitive examination for detecting early dementia in a Japanese population. Psychiatry Res. 185: 211-214, 2011.
Kishimoto Y, Terada S, Sato S, Takeda N, Honda H, Yokota O, Uchitomi Y. Kana Pick-out Test and brain perfusion imaging in Alzheimer's disease. Int Psychogeriatr. 23(4): 546-553, 2011. doi: 10.1017/S1041610210001961
Terada S, Sato S, Honda H, Kishimoto Y, Takeda N, Oshima E, Yokota O, Uchitomi Y. Perseverative errors on Wisconsin card sorting test and brain perfusion imaging in mild Alzheimer’s disease. Int. Psychogeriatr. 23: 1552-1559, 2011.

2010年
Takeda N, Terada S, Sato S, Honda H, Yoshida H, Kishimoto Y, Kamata G, Oshima E, Ishihara T, Kuroda S. Wisconsin Card Sorting Test and Brain Perfusion Imaging in Early Dementia. Dement. Geriatr. Cogn. Disord. 29: 21-27, 2010.
Kishimoto Y, Terada S, Sato S, Yoshida H, Honda H, Takeda N, Oshima E, Ishihara T, Kuroda S. Repetitive questioning behavior in Alzheimer’s disease: relationship to regional cerebral blood flow. Psychiatry Res. 184: 151-156, 2010.
Ata T, Terada S, Yokota O, Ishihara T, Fujisawa Y, Sasaki K, Kuroda S. Wandering and fecal smearing in people with dementia. Int. Psychogeriatr. 22: 493-500, 2010.